Selection of Vials for Yingtai Freeze Dryers

Selection of Vials for Yingtai Freeze Dryers  

Vials are commonly used as packaging containers for products such as lyophilized powder injections, biological preparations, and cosmetic freeze-dried powders. Selecting the appropriate vials for freeze dryers is crucial for the stability of the lyophilization process, product sealing, and long-term storage.  

The capacity of the vials should be determined based on the filling volume of the lyophilized product and the lyophilization process. Common specifications include:  

- 1mL, 2mL: For small-dose lyophilized powders  

- 3mL, 5mL, 7mL: For cosmetic freeze-dried powders and freeze-dried essences  

- 10mL, 20mL: For lyophilized preparations with larger filling volumes  

Borosilicate glass vials are primarily used for lyophilization. Soda-lime glass lacks sufficient chemical stability, and its alkaline ions may leach into the drug, affecting the quality, safety, and efficacy of the lyophilized powder. Borosilicate glass vials have a high boron content and a low coefficient of expansion, whereas the opposite is true for glass with a lower boron content. Lyophilization requires a low coefficient of expansion because the vials contract during freezing, while water expands when frozen into ice.  

After lyophilization, the product volume expands. It is essential to reserve 30% to 50% of the vial space to prevent powder overflow post-lyophilization. The filling height should generally not exceed two-thirds of the vial height to ensure proper moisture sublimation during the lyophilization process.