Yingtai：Application of Lyophilization Technology in Powdered Pharmaceuticals

Yingtai：Application of Lyophilization Technology in Powdered Pharmaceuticals

The application of lyophilization technology in powdered pharmaceuticals is based on its unique low-temperature drying process, which is particularly suitable for heat-sensitive substances such as active proteins and microbial preparations. Powdered pharmaceuticals prepared by lyophilization have significant advantages, including good stability, high bioavailability, rapid onset of action, and high technical content .

The preparation process of lyophilized powder injection mainly includes the steps of drug preparation, dispensing, pre-freezing, drying and post-treatment. In the pre-freezing stage, the drug solution is rapidly cooled down to a frozen state, and this step is crucial to ensure the stability of the drug molecular structure. The drying stage is the core of the lyophilization process and removes water from the drug solution by sublimation in two stages: the first stage removes free water, and the second stage removes bound and adsorbed water. Post-processing includes sealing, testing and packaging to ensure the sterility and hermeticity of the lyophilized powder injection .

Lyophilized powder injection has a significant stability advantage over ordinary powder injection and aqueous injection, with extremely low water content (<0.01%), which is not easy to be hydrolyzed and oxidized. In addition, lyophilized powder injections have higher bioavailability and faster onset of action due to the ice shelf structure formed during the lyophilization process, which expands the surface area of the drug. Lyophilized powder injections have high technological content, and can achieve rapid, targeted or controlled release of drugs through microencapsulation or the formation of liposomes and other technologies .

With the continuous progress of pharmaceutical technology, lyophilized powder injection is expected to be more widely used in the pharmaceutical field due to its advantages in stability, bioavailability and production efficiency, especially in the development of Chinese medicine preparation, lyophilization technology will bring new opportunities and challenges.

EX series of pilot R&D type lyophilizers are high-end R&D type lyophilizers launched by Yingtai, and this series of lyophilizers have the following advantages:

①The shelf is highly leveled, and the silicone oil conducts heat uniformly.

Vacuum is precisely controllable, higher freeze-drying efficiency.

③Mechanical compound refrigeration, refrigeration system is stable.

④ Equipped with cap function, precise plugging to protect the samples.

⑤The whole lyophilization process can be controlled to better realize the lyophilization process exploration.

In addition, the PC software is developed by Yingtai from the underlying code source, and the software can be iteratively changed at any time according to the user's requirements. The comprehensive performance of the equipment far exceeds that of similar models. It is the preferred equipment for freeze-drying powder medicine.